DDT - A Versatile Tunneling Technology

Directed evolution of an orthogonal nucleoside analog kinase via fluorescence-activated cell sorting

Nucleoside analogs (NAs) represent an important category of prodrugs for the treatment of viral infections and cancer, yet the biological potency of many analogs is compromised by their inefficient activation through cellular 2'-deoxyribonucleoside kinases (dNKs). We herein report the directed evolution and characterization of an orthogonal NA kinase for 3'-deoxythymidine (ddT), using a new FAC...

A Versatile , Stable Scanning Proximal Probe Microscope

We present a novel scanning proximal probe microscope design utilizing a piezo-electric driven coarse positioning mechanism in x, y, and z, while maintaining relatively small lateral dimensions. The instrument is suitable for insertion into a dewar. The primary purpose of this work is to develop a stable yet versatile instrument in order to meet the signal averaging limitations imposed by low s...

The strange career of DDT: experts, federal capacity, and environmentalism in World War II.

Using information on uncertainty to improve environmental fate modeling: a case study on DDT.

Present and future concentrations of DDT in the environment are calculated with the global multimedia model CliMoChem. Monte Carlo simulations are used to assess the importance of uncertainties in substance property data, emission rates, and environmental parameters for model results. Uncertainties in the model results, expressed as 95% confidence intervals of DDT concentrations in various envi...

Applicability of Elastic Analysis for Predicting the Settlement Distribution Around Tunneling in Soft Ground (TECHNICAL NOTE)

In this article a brief review of the literature on the subject is cited. The method of analysis by a finite element program is discussed in which the effect of different influential parameters are examined. The results of these computations are then compared to the corresponding empirical data and two other existing formulae for two dimensional cases. The comparisons show quite reliable and ac...